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However, tendons and muscle insertions are put under greater demands with increased muscle strength and consequently, decreased collagen quality may predispose these structures to ruptures. This study protocol did not examine the effect of increased load on tendon. High doses of AAS were found to enhance collagen synthesis, especially in soft connective tissues. During the AAS cycle soft connective tissue collagen metabolism was increased. This effect tended to be dose-dependent. Degradation of type I collagen, by contrast tended to diminish collagen type I is most abundant in bone tissue (Melkko et al. Urinary lysylpyridinoline (LP) mature crosslinks of collagen values remained unchanged.

 

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